科研成果

Sun L, Bian Y, Yang D, Miao R, Meng Y, Che J, Li Z, Li Z, Wang H, Wu S, Meng J, Wang Y,   Griffin C, Yau ST, Wu R. Graph statistics theory of individualized quantitative genetics under haplotype-resolved genome assembly. Proc Natl Acad Sci U S A. 2026 Apr 7;123(14):e2600004123. doi: 10.1073/pnas.2600004123. Epub 2026 Mar 31. PMID: 41915744; PMCID: PMC13056068.

Xu S, Wang Y, Wu S, Wang Y, Dong A, Shing-Toung Yau S, Yau ST, Wu R. Statistical learning of stochastic complex systems via the Yau-Yau nonlinear filter. Innovation (Camb). 2026 Jan 15;7(6):101267. doi: 10.1016/j.xinn.2026.101267. PMID: 42254969; PMCID: PMC13237851.

Zhang Z, Fan X, Zhong J, Jia L, Han Y, Yang C, He Z, Li X, Yau ST, Wu R, Danko CG, Wang Z. An end-to-end generalizable deep learning framework to comprehensively analyze transcriptional regulation. Nat Commun. 2026 Apr 1;17(1):4708. doi: 10.1038/s41467-026-70070-6. PMID: 41922356; PMCID: PMC13212934.

Dong A, Meng Y, Yau SS, Yau ST, Wu R. A Statistical Mechanics Model to Decode Tissue Crosstalk During Graft Formation. Adv Sci (Weinh). 2026 Feb;13(10):e23373. doi: 10.1002/advs.202523373. Epub 2026 Jan 7. PMID: 41498655; PMCID: PMC12915093.

Fa C, Wang G, Pan W, Wang Y, Che J, Dong A, Yang D, Wu R, Yau ST, Sun L. An omnigenic interactome model to chart the genetic architecture of individual plants. Hortic Res. 2025 Dec 16;13(3):uhaf345. doi: 10.1093/hr/uhaf345. PMID: 41821682; PMCID: PMC12977963.

Wang Y, Zhao J, He X, Yang D, Jin Y, Wu R. A Computational Ecological Genetic Model of Phenotypic Plasticity in Species Interactions. Mol Ecol Resour. 2026 Jan;26(1):e70095. doi: 10.1111/1755-0998.70095. PMID: 41491638; PMCID: PMC12770817.

Pan W, Che J, Wu S. 2026. An improved method of Wu’s functional clustering. Statistics Innovation 3: e005 doi: 10.48130/stati-0026-0006

Che, J. (2026). From adaptive networks to expanding state spaces: Comment on “Beyond networks: Toward adaptive models of biological complexity” by Pessoa. Physics of Life Reviews, 56, 126–127. https://doi.org/10.1016/j.plrev.2025.12.010

Sun N, Wang Y, Shi X, Yang D, Wu R, Yau SS. scMFF: a machine learning framework with multiple feature fusion strategies for cell type identification. BMC Bioinformatics. 2025 Nov 18;26(1):277. doi: 10.1186/s12859-025-06309-8. PMID: 41254497; PMCID: PMC12625116.

Wang Y, Wu R. Network stress: a wiring diagram of whole stress genes. Hortic Res. 2025 Oct 29;13(2):uhaf302. doi: 10.1093/hr/uhaf302. PMID: 41756043; PMCID: PMC12933664.

Temesgen S, Kedir R, Wang Y, Tulu TW. 2026. Estimating time-to-death and determining risk predictors of heart failure patients. Statistics Innovation 3: e001 doi: 10.48130/stati-0026-0001

Zhang, Han and Jincan Che. “Data-driven design of electromagnetic functional materials: a statistical perspective.” Statistics Innovation (2025): n. pag.

Che J, Wang Y, Feng L, Gragnoli C, Griffin C, Wu R. High-order interaction modeling of tumor-microenvironment crosstalk for tumor growth. Phys Life Rev. 2025 Sep;54:11-23. doi: 10.1016/j.plrev.2025.05.007. Epub 2025 May 16. PMID: 40412053.

Wang, Y., Sun, N., Che, J., Griffin, C., Gragnoli, C., & Jiang, L. (2025). GameTalker: Tracing cell–cell communication in tumorigenesis across boundaries. Data Analytics and Topology, 1(2), 143–152. https://doi.org/10.4310/DAT.260127002543

Sun Z, Ye J, Sun W, Jiang L, Shan B, Zhang M, Xu J, Li W, Liu J, Jing H, Zhang T, Hou M, Xie C, Wu R, Pan H, Yuan J. Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis. Nat Commun. 2025 Feb 22;16(1):1890. doi: 10.1038/s41467-025-57211-z. PMID: 39987261; PMCID: PMC11846980.

Wang, B., Zheng, S., Wu, J. et al. Inverse design of catalytic active sites via interpretable topology-based deep generative models. npj Comput Mater 11, 147 (2025). https://doi.org/10.1038/s41524-025-01649

Yao, J.; Li, J.; Wu, J.; Yang, M.; Wang, X. Change Point Detection in Financial Market Using Topological Data Analysis. Systems 2025, 13, 875. https://doi.org/10.3390/systems13100875

Li, P., Pan, J. and Wu, J. (2025), Cohomotopy sets of (n−1)-connected (2n +2)-manifolds for small n. Trans. London Math. Soc., 12: e70010. https://doi.org/10.1112/tlm3.70010

Wang, Y., Xu, S., Wei, X., Luo, X., Yau, S.S., Yau, S., & Wu, R. (2025). Yau-YauAL: A computer tool for solving nonlinear filtering problems. Data Analytics and Topology.

Dror Farjoun, E., Ivanov, S. O., Krasilnikov, A., & Zaikovskii, A. (2025). A note on the non-existence of functors. Journal of Algebra, 675, 273–288. https://doi.org/10.1016/j.jalgebra.2025.03.037

Wu, S., & Zhang, M. (2025). Disentangling complex systems: IdopNetwork meets GLMY homology theory [Preprint]. arXiv:2505.04140. https://doi.org/10.48550/arXiv.2505.04140

Dror Farjoun, E., & Ivanov, S. O. (2025). Bousfield–Kan completion as a codensity ∞-monad [Preprint]. arXiv:2507.08414. https://doi.org/10.48550/arXiv.2507.08414

Hu, Y., Kang, J., Ma, L., & Zhang, X. (2025). A novel implementation of Yau–Yau filter for time-variant nonlinear problems [Preprint]. arXiv:2505.03240. https://doi.org/10.48550/arXiv.2505.03240

Li, J., Muranov, Y., Wu, J., & Yau, S.-T. (2024). Primitive path homology [Preprint]. arXiv. https://doi.org/10.48550/arXiv.2411.18955

Lin, X., Zi, Y., Li, F., & Li, J. (2024). New aspects of analyzing amyloid fibrils [Preprint]. arXiv:2405.14370. https://doi.org/10.48550/arXiv.2405.14370